Santa Croce Vacations from $923
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Your Santa Croce Vacation
Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.
The Latest Santa Croce Vacation Packages
Hotel Ginori al DUOMO
Reviewed on Sep 4, 2026
Grand Hotel Cavour
Reviewed on Sep 12, 2026
Where to stay in Santa Croce
Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Duomo
Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence.
Santa Maria Novella
Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.
Oltrarno
South of the River Arno, this quarter boasts part of Florence's historic center, featuring notable sites like Santo Spirito di Firenze, Palazzo Pitti, Belvedere, and Piazzale Michelangelo.
Santa Croce Hotel Deals
Plaza Hotel Lucchesi
"I normally don’t bother commenting on reviews, but the expectations vs reality of this place were significant. Rooms are average, at best, shower leaked, parts of the walls are coming off etc. no big deal if this was advertised as a ‘normal’ stay. Be prepared for a 3 star, at best experience. Also, ..."
Reviewed on Sep 11, 2026
FH55 Grand Hotel Mediterraneo
"Fantastic hotel, staff helpful, amazing clean rooms, breakfast buffet, great, a real big spread with many options, freshly squeezed juice, staff, helpfull at all times..."
Reviewed on Sep 11, 2026
LHP Hotel River & SPA
"The staff was really great. We did the check-in with Costanza, who was very nice, knowledgeable, and welcoming. We felt very comfortable immediately. The room was clean, a bit small and comfortable. The breakfast was really good with many different choices for everyone. We really enjoyed our stay ..."
Reviewed on Sep 3, 2026
Stay near popular Santa Croce attractions
Piazza Santa Croce
Basilica of Santa Croce
Teatro Verdi
Church of Sant'Ambrogio
Mercato di Sant'Ambrogio
National Central Library of Florence
Casa Buonarroti
I Mosaici Di Lastrucci
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Pasta Cooking Class with Unlimited Wine
