Santa Croce Vacations from $638

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,052, price is now $638 per person
$638
per person
Feb 25 - Mar 3
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.6/10 Good! (1,002 reviews)
9 day stay. The property hit my must-haves! Central location, clean, affordable, and safe. 5/5 in all these areas! There is nothing they can do about dirty streets but the filth did not cross the threshold. T2 tram from the airport is 2 blocks away. The central market is 2 blocks in the other direction. Key card swipe after dark. 24 hour desk service. Breakfast on the 5th floor with views. Very courteous staff. The only complaint is breakfast tables are cleared very quickly while I went for a americano refill. Will definitely return here.

Reviewed on Jan 3, 2026

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,138, price is now $668 per person
$668
per person
Feb 25 - Mar 3
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,000 reviews)
Great Locations walkable to all the placese.

Reviewed on Dec 15, 2025

Hotel degli Orafi

Hotel degli Orafi

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $2,354, price is now $1,626 per person
$1,626
per person
Feb 25 - Mar 3
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (1,001 reviews)
Staff is great. Beautiful view of the duomo in the bar.

Reviewed on Jan 4, 2026

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

4 out of 5
Historic Centre of Florence
Price was $1,294, price is now $902 per person
$902
per person
Feb 25 - Mar 3
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (495 reviews)
The spa was wonderful though the jacuzzi could be hotter I think! The only complaint was that the bed wasn’t very comfortable (it was pretty hard) and the pillows were rather flat.

Reviewed on Jan 2, 2026

Art Atelier

Art Atelier

4 out of 5
Historic Centre of Florence
Price was $1,146, price is now $808 per person
$808
per person
Feb 25 - Mar 3
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.2/10 Wonderful! (1,001 reviews)
The room was spacious and the terrace was very nice. The hotel is in walking distance to all the attractions and train station.

Reviewed on Jan 6, 2026

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Aurum Uffizi

Aurum Uffizi

4 out of 5
Via Osteria Del Guanto 6 Florence FI
$172 nightly
The price is $205 total per night from Jan 26 to Jan 27
$205 total
Jan 26 - Jan 27
Total with taxes and fees
7.6/10 Good! (1,001 reviews)
The room was fine and the staff friendly. However sometimes was not staffed in the afternoons and never after 1030.

Reviewed on Dec 19, 2025

Aurum Uffizi
LHP Hotel River & SPA

LHP Hotel River & SPA

5 out of 5
Lungarno Della Zecca Vecchia 18 Florence FI
$172 nightly
The price is $208 total per night from Feb 5 to Feb 6
$208 total
Feb 5 - Feb 6
Total with taxes and fees
8.8/10 Excellent! (249 reviews)
Very nice location. Staff are very attentive and helpful. Nice indoor outdoor bar. Excellent breakfast buffet.

Reviewed on Dec 12, 2025

LHP Hotel River & SPA
Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $209 total per night from Feb 4 to Feb 5
$209 total
Feb 4 - Feb 5
Total with taxes and fees
9.2/10 Wonderful! (979 reviews)
Excellent location. Staff was accommodative of our needs.

Reviewed on Dec 30, 2025

Plaza Hotel Lucchesi
See all 851 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

4/5(5 reviews)

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

4.5/5(990 reviews)

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and stunning cathedral.

National Central Library of Florence

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$24
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence: Timed Entrance Ticket to Michelangelo’s David

Florence: Timed Entry to Michelangelo's David + Audio App

$28
per adult
88% of travellers recommend
Florence: Timed Entry to Michelangelo's David + Audio App
Micheal Angelo's David

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$36
per adult
86% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.