Santa Croce Vacations from $1,378
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Your Santa Croce Vacation
Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.
The Latest Santa Croce Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Aurum Uffizi
Historic Centre of Florence
Price was $2,473, price is now $1,522 per person
$1,522
per person
Jun 3 - Jun 9
found 3 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
7.6/10 Good! (1,000 reviews)
The room was clean and newly renovated. Having breakfast included was great for a quick bite so I could focus on exploring instead of searching and waiting in line. Would definitely recommend a stay here
Reviewed on Apr 9, 2026
The Moon Boutique Hotel & Spa
Historic Centre of Florence
Price was $2,663, price is now $1,855 per person
$1,855
per person
Jun 23 - Jun 29
found 3 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (515 reviews)
This is a great hotel but a bit far from our points of interest. Staff are amazing and so is the spa. Breakfast is great, everything included with your stay except for 2 items on the menu which was a little strange (fresh fruit plate and egg Benedict), not sure why they decided to charge for these 2 items. I think it would have been a better customer experience to include both, but not a deal breaker as there were enough options. The beds were hard and not very comfortable for us and it was very hot our first 2 days as we were told A/C could not be turned on until april 20th or when temps reach 80 degrees. The rooms were exceptionally clean. Overall a very good hotel but not sure we would stay again.
Reviewed on Apr 10, 2026
Precise Tale Poggio Alla Sala
Save 100% on your flight
Price was $4,065, price is now $2,853 per person
$2,853
per person
May 22 - May 26
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Florence (FLR)
9.4/10 Exceptional! (124 reviews)
Most gorgeous setting, lovely staff and delicious food. We will definitely be back!
Reviewed on Apr 5, 2026
Portrait Firenze - Lungarno Collection
Historic Centre of Florence
Save 100% on your flight
Price was $6,294, price is now $4,493 per person
$4,493
per person
Jun 3 - Jun 9
found 3 hours ago
Roundtrip non-stop flight included
New York (JFK) to Florence (FLR)
9.8/10 Exceptional! (307 reviews)
The rooms are beautiful and immaculately kept. The staff is so personable and thoughtful. The location is unmatched highly recommend this hotel!
Reviewed on Apr 3, 2026
Where to stay in Santa Croce
Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Historic Centre of Florence
10 out of top 10 points of interest in this area
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santa Croce Hotel Deals
Plaza Hotel Lucchesi
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$319 nightly
The price is $368 total per night from Apr 19 to Apr 20
$368 total
Apr 19 - Apr 20
Total with taxes and fees
9.4/10 Exceptional! (1,004 reviews)
I have stayed here every year for the past 12 years. Consistently wonderful. Excellent location and the staff is impeccable and friendly. I highly recommend
Reviewed on Apr 10, 2026
Aurum Uffizi
Via Osteria Del Guanto 6 Florence FI
$392 nightly
The price is $448 total per night from Apr 26 to Apr 27
$448 total
Apr 26 - Apr 27
Total with taxes and fees
7.6/10 Good! (1,004 reviews)
The room was clean and newly renovated. Having breakfast included was great for a quick bite so I could focus on exploring instead of searching and waiting in line. Would definitely recommend a stay here
Reviewed on Apr 9, 2026
FH55 Grand Hotel Mediterraneo
Lungarno del Tempio, 44 Florence FI
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $205 total per night from Apr 12 to Apr 13
$205 total
Apr 12 - Apr 13
Total with taxes and fees
8.2/10 Very Good! (985 reviews)
The staff was re
Reviewed on Apr 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Croce
Piazza Santa Croce
4/5(5 reviews)
Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.
Basilica of Santa Croce
4.5/5(1,000 reviews)
Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.
Church of Sant'Ambrogio
4/5(5 reviews)
After visiting Church of Sant'Ambrogio, make a plan to see the other sights and activities in Florence. Stroll along the riverfront or visit the notable monuments in this vibrant area.
Things to do
Small-Group Wine Tasting Experience in the Tuscan Countryside
$102
per adult
98% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
$26
per adult
80% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
$36
per adult
86% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.