Santa Croce Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

Price found within the past 48 hours. Click for updated prices.
  • Aug 17 - Aug 27

    Aurum Uffizi + Flight

    Historic Centre of Florence
    9 nights
    4.0 star property
    7.6/10 - Good (1,011 reviews)
    "The hotel was conveniently located, and the service was good. Overall, it was a pleasant stay. However, I hope the hotel improves its Wi-Fi coverage, as the connection can become unstable when multiple guests are accessing the network."
    Reviewed June 5, 2026
    Roundtrip New York (JFK) - Florence (FLR)
    JFK - FLR1 stop FLR - JFK1 stop
    Save 100% on your flight
    $1,957
    $1,083
    per traveler
    found 1 day ago
    Aurum Uffizi
  • Aug 8 - Aug 16

    Aurum Firenze + Flight

    Historic Centre of Florence
    7 nights
    4.0 star property
    7.6/10 - Good (1,018 reviews)
    "Très bien situé, tout près du centre. Terrasse pour le déjeuner très agréable! Chambre bien aménagée et pratique."
    Reviewed June 5, 2026
    Roundtrip Boston (BOS) - Florence (FLR)
    BOS - FLR1 stop FLR - BOS1 stop
    $1,929
    $1,220
    per traveler
    found 17 hours ago
    Aurum Firenze
  • Jul 10 - Jul 19

    Donati Luxury Tower Suites + Flight

    Historic Centre of Florence
    8 nights
    5.0 star property
    9.8/10 - Exceptional (66 reviews)
    "Agradable estancia. Excelente servicio. La habitación la mantenían siempre limpia. Todo queda cerca del área. Muy recomendable"
    Reviewed May 23, 2026
    Roundtrip Columbus (GTR) - Florence (FLR)
    GTR - FLR2 stops FLR - GTR2 stops
    Save 100% on your flight
    $8,233
    $5,264
    per traveler
    found 1 day ago
    Donati Luxury Tower Suites
  • Aug 15 - Aug 27

    Hotel degli Orafi + Flight

    Historic Centre of Florence
    11 nights
    4.0 star property
    9.6/10 - Exceptional (1,004 reviews)
    "No view and the room was very awkwardly shaped"
    Reviewed May 30, 2026
    Roundtrip New York (JFK) - Florence (FLR)
    JFK - FLR1 stop FLR - JFK1 stop
    Save 100% on your flight
    $2,852
    $1,853
    per traveler
    found 1 day ago
    Hotel degli Orafi
  • Jul 10 - Jul 19

    The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World + Flight

    Historic Centre of Florence
    8 nights
    5.0 star property
    10/10 - Exceptional (18 reviews)
    Roundtrip Columbus (GTR) - Florence (FLR)
    GTR - FLR2 stops FLR - GTR2 stops
    Save 100% on your flight
    $6,308
    $4,349
    per traveler
    found 1 day ago
    The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$299 nightly
The price is $345 total per night from Jul 5 to Jul 6
$345 total
Jul 5 - Jul 6
Total with taxes and fees
9.4/10 Exceptional! (1,005 reviews)
"Beautiful property, nice rooftop"

Reviewed on Jun 6, 2026

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44 Florence FI
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $180 total per night from Jul 3 to Jul 4
$180 total
Jul 3 - Jul 4
Total with taxes and fees
8.2/10 Very Good! (1,004 reviews)
"Staff was very friendly and helpful. The breakfast was fantastic. Any little issues that came up were quickly dealt with. A great stay."

Reviewed on Jun 5, 2026

FH55 Grand Hotel Mediterraneo
Aurum Uffizi

Aurum Uffizi

4 out of 5
Via Osteria Del Guanto 6 Florence FI
$243 nightly
The price is $284 total per night from Jul 1 to Jul 2
$284 total
Jul 1 - Jul 2
Total with taxes and fees
7.6/10 Good! (1,011 reviews)
"Room was spacious and clean. Air con was a real bonus."

Reviewed on Jun 6, 2026

Aurum Uffizi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Croce

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.