Santa Croce Vacations from $902

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Save 100% on your flight
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.6/10 Good! (1,007 reviews)
Great location. Few minutes away from train station. Not so quiet. You could hear people from outside even the windows closed. If you are staying for a few days, it’s a great location.

Reviewed on Aug 14, 2025

Palazzo Firenze by Baglioni Hotels & Resorts

Palazzo Firenze by Baglioni Hotels & Resorts

5 out of 5
Historic Centre of Florence
per person
Oct 3 - Oct 8
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.4/10 Exceptional! (230 reviews)
I VERY MUCH ENJOYED THE STAY

Reviewed on Jul 18, 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Save 100% on your flight
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,000 reviews)
Great location and very clean

Reviewed on Aug 12, 2025

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Save 100% on your flight
per person
Oct 18 - Oct 24
found 14 hours ago
Roundtrip flight included
Los Angeles (LAX) to Florence (FLR)
9.8/10 Exceptional! (218 reviews)
AMAZING! Gorgeous! I would recommend to everyone!

Reviewed on Jul 29, 2025

LHP River Club

LHP River Club

5 out of 5
Santa Croce
Save 100% on your flight
per person
Oct 2 - Oct 7
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
10/10 Exceptional! (1 review)

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38, Florence, FI
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $323 total per night from Aug 24 to Aug 25
$323 total
Aug 24 - Aug 25
Total includes taxes and fees
9.2/10 Wonderful! (975 reviews)
Great rooftop
"Great family rooms; pool has amazing views and nice bar; staff friendly and easy check in and out"

Reviewed on Aug 15, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44, Florence, FI
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $134 total per night from Aug 23 to Aug 24
$134 total
Aug 23 - Aug 24
Total includes taxes and fees
8/10 Very Good! (901 reviews)
"Bed comfort, walking and food options"

Reviewed on Aug 11, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri

Hotel Balestri

4 out of 5
Piazza Mentana 7, Florence, FI
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $212 total per night from Aug 25 to Aug 26
$212 total
Aug 25 - Aug 26
Total includes taxes and fees
9.2/10 Wonderful! (971 reviews)
"Pros: The staff were all wonderful with anything we needed! Especially when we had an incident with our luggage arriving late. The breakfast was absolutely delightful. Super close to museums. Cons: rooms are small and beds are tiny. The "rooftop" is a joke. There was construction goin on right outside ..."

Reviewed on Aug 14, 2025

Hotel Balestri
See all 824 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and stunning cathedral.

National Central Library of Florence

Things to do

Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$33
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
People riding scooters in Tuscany

Tuscany Vintage Vespa Tour

$151
per adult
100% of travellers recommend
Tuscany Vintage Vespa Tour
Santa Maria Novella

Visit Florence in golf car with Fiorentine tuorist guide

$80
per adult
100% of travellers recommend
Visit Florence in golf car with Fiorentine tuorist guide
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.