Santa Croce Vacations from $641

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Florence Boutique

Eurostars Florence Boutique

4 out of 5
Historic Centre of Florence
Price was $918, price is now $641 per person
$641
per person
Dec 8 - Dec 14
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.6/10 Excellent! (472 reviews)
Great little hotel. Everything is within walking distance. The view from the terrace was amazing.

Reviewed on Aug 6, 2025

Villa Cora

Villa Cora

5 out of 5
Oltrarno
Save 100% on your flight
Price was $1,988, price is now $1,358 per person
$1,358
per person
Dec 7 - Dec 12
found 8 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.8/10 Exceptional! (461 reviews)
The hotel is very beautiful, and the surrounding environment is also excellent.

Reviewed on Sep 26, 2025

Dimora Palanca Boutique & SPA

Dimora Palanca Boutique & SPA

5 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,664, price is now $1,151 per person
$1,151
per person
Nov 16 - Nov 22
found 20 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.4/10 Exceptional! (51 reviews)
Overall the property was great for our needs. It was very convenient for us because it had parking on the premises. The staff was amazing and the king room was beautiful. The only drawback is that it was a bit of a walk from the city center.

Reviewed on Oct 5, 2025

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $1,639, price is now $1,138 per person
$1,138
per person
Dec 28 - Jan 1
found 10 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,007 reviews)
Breakfast was excellent

Reviewed on Sep 29, 2025

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Historic Centre of Florence
Price was $1,403, price is now $977 per person
$977
per person
Dec 8 - Dec 14
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.4/10 Exceptional! (1,004 reviews)
After 1 night we were given the actual room we had booked and it was great

Reviewed on Oct 3, 2025

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38, Florence, FI
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $251 total per night from Nov 3 to Nov 4
$251 total
Nov 3 - Nov 4
Total with taxes and fees
9.2/10 Wonderful! (983 reviews)
"The staff was amazing!! Very clean and convenient"

Reviewed on Oct 1, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44, Florence, FI
$153 nightly
The price is $185 total per night from Nov 2 to Nov 3
$185 total
Nov 2 - Nov 3
Total with taxes and fees
8/10 Very Good! (929 reviews)
"We enjoyed the walkable location of the hotel. The breakfast was the best of any hotel during our 2 weeks in Italy. Dinner at the hotel was delicious, out of convenience we ate there a couple nights. The room was comfortable and clean."

Reviewed on Sep 29, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri

Hotel Balestri

4 out of 5
Piazza Mentana 7, Florence, FI
Fully refundableReserve now, pay when you stay
$227 nightly
The price is $266 total per night from Nov 3 to Nov 4
$266 total
Nov 3 - Nov 4
Total with taxes and fees
9.2/10 Wonderful! (994 reviews)
"Love it"

Reviewed on Oct 3, 2025

Hotel Balestri
See all 823 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and notable monuments.

National Central Library of Florence

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$25
per adult
76% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence: Reserved Entry Ticket to Bargello Museum

Florence: Reserved Entry Ticket to Bargello Museum

$19
per adult
Florence: Reserved Entry Ticket to Bargello Museum
Florence half day combo tour with David, Uffizi & Duomo

Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia

$48
per adult
90% of travellers recommend
Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.